abstract：CONCLUSION:An 18-mer peptide derived from the neurotrophic region of prosaposin (PS-pep) prevents hearing loss and cochlear damage due to transient cochlear ischaemia by activating an anti-apoptotic pathway. PS-pep is a potent candidate molecule for alleviating ischaemia-induced hearing loss. OBJECTIVE:PS-pep was inve...

journal_title：Acta oto-laryngologica

authors： Terashita T,Saito S,Nabeka H,Hato N,Wakisaka H,Shimokawa T,Kobayashi N,Gyo K,Matsuda S

更新日期：2013-05-01 00:00:00

abstract：CONCLUSION:This study showed that elective neck dissection (ND) resulted in reduced regional recurrences in a selected group of surgically treated patients with pT1-2 carcinomas but did not show any benefit for disease-specific survival (DSS). Furthermore, the importance of pN classification was also verified for this ...

journal_title：Acta oto-laryngologica

authors： Psychogios G,Mantsopoulos K,Koch M,Klintworth N,Kapsreiter M,Zenk J,Iro H

更新日期：2013-03-01 00:00:00

abstract：CONCLUSION:The midline electroneurography (ENoG) method might reflect total facial nerve degeneration. OBJECTIVE:We compared ENoG values in patients with facial palsy using two different methods, the midline method and five electroneurogram recordings, to reveal whether the ENoG value obtained with the midline method ...

journal_title：Acta oto-laryngologica

authors： Wada S,Haginomori S,Mori A,Ichihara T,Kanazawa A,Kawata R,Takubo T,Yorifuji S

更新日期：2013-03-01 00:00:00

abstract：CONCLUSION:Mouse embryonic stem cells (ESCs) transplanted into the scala tympani are able to migrate in the cochlea of rats deafened with aminoglycoside and partly restore the structure of sensory epithelia of the inner ear. OBJECTIVES:To explore the migration and differentiation of enhanced green fluorescence protein...

journal_title：Acta oto-laryngologica

authors： Zhao LD,Li L,Wu N,Li DK,Ren LL,Guo WW,Sun JH,Liu HZ,Chen ZT,Xing GQ,Yang SM

更新日期：2013-02-01 00:00:00

abstract：CONCLUSION:Utricular dysfunction in patients with posterior canal benign paroxysmal positional vertigo (pBPPV) was supported by findings for ocular vestibular evoked myogenic potential (oVEMP). OBJECTIVE:To evaluate the utricular and saccular function in patients with pBPPV. METHODS:This study focused on 12 patients ...

journal_title：Acta oto-laryngologica

authors： Nakahara H,Yoshimura E,Tsuda Y,Murofushi T

更新日期：2013-02-01 00:00:00

abstract：CONCLUSION:The use of both gadolinium chloride (GdCl(3)) and osmium tetroxide (OsO(4)) allowed for the visualization of the membranous labyrinth and other intralabyrinthine structures, at different intensities, as compared with the control sample. This initial comparison shows the advantages of GdCl(3) in radiological ...

journal_title：Acta oto-laryngologica

authors： Wong CC,Curthoys IS,O'Leary SJ,Jones AS

更新日期：2013-01-01 00:00:00

abstract：CONCLUSION:Vibrant Soundbridge (VSB) application to the middle ear windows yields better functional outcomes than conventional hearing aids. However, speech discrimination scores obtained with VSB and conventional hearing aids are similar. OBJECTIVE:To assess audiological outcomes of round and oval window applications...

journal_title：Acta oto-laryngologica

authors： Gunduz B,Atas A,Bayazıt YA,Goksu N,Gokdogan C,Tutar H

更新日期：2012-12-01 00:00:00

abstract：CONCLUSION:The age-related changes in ocular vestibular-evoked myogenic potentials (oVEMPs) elicited by galvanic vestibular stimulation (GVS) and bone-conducted vibration (BCV) might be attributed to the morphological degeneration of the vestibular system. OBJECTIVE:This study employed GVS and BCV modes for eliciting ...

journal_title：Acta oto-laryngologica

authors： Chang CM,Young YH,Cheng PW

更新日期：2012-12-01 00:00:00

abstract：CONCLUSION:Nasal obstruction, rhinorrhea, and the amount of rhinorrhea that confidently reflect the parasympathetic stimulation can be used to more precisely predict nonspecific nasal hyper-reactivity (NHR). OBJECTIVE:We aimed to identify factors that confidently reflected the presence and the degree of NHR, measured ...

journal_title：Acta oto-laryngologica

authors： Kim YH,Jang TY

更新日期：2012-10-01 00:00:00

abstract：CONCLUSIONS:These findings are in line with previous data on the horizontal vestibulo-ocular reflex (VOR) from this laboratory and suggest that eye position signals do not modulate natural vestibular responses. Hence, the Alexander's law (AL) phenomenon cannot be interpreted simply as a consequence of vestibular or ocu...

journal_title：Acta oto-laryngologica

authors： Anastasopoulos D,Anagnostou E

更新日期：2012-10-01 00:00:00

abstract：CONCLUSION:Transforming growth factor β1 gene (TGFβ1) genotype is a potential p16 independent prognostic factor predicting response to chemoradiotherapy in head and neck squamous cell carcinoma (HNSCC). OBJECTIVES:Expression of p16 and epidermal growth factor receptor (EGFR) has been reported to be associated with sur...

journal_title：Acta oto-laryngologica

authors： Lundberg M,Leivo I,Saarilahti K,Mäkitie AA,Mattila PS

更新日期：2012-09-01 00:00:00

abstract：CONCLUSION:Given the phonetic balancing across lists and the validation with spectrally degraded speech, the present Mandarin disyllable recognition test (DRT) materials may be useful for assessing speech performance of Mandarin-speaking cochlear implant (CI) users. If combined with the previously developed sentence ma...

journal_title：Acta oto-laryngologica

authors： Zhu M,Wang X,Fu QJ

更新日期：2012-08-01 00:00:00

abstract：CONCLUSION:The clinical presentation and outcome of post-traumatic benign paroxysmal positional vertigo (t-BPPV) are different from those idiopathic BPPV (i-BPPV). It appears that t-BPPV is more difficult to treat than i-BPPV. OBJECTIVE:To identify the clinical presentation and outcome of t-BPPV. METHODS:We reviewed ...

journal_title：Acta oto-laryngologica

authors： Liu H

更新日期：2012-08-01 00:00:00

abstract：CONCLUSIONS:Auricle reconstruction combined with hearing reconstruction can help patients with microtia to obtain practical hearing improvement as well as cosmetic improvement. The integrated procedures can facilitate the incision design and obtain a natural-looking three-dimensional shape of the reconstruction auricle...

journal_title：Acta oto-laryngologica

authors： Zhao S,Wang D,Han D,Gong S,Ma X,Li Y,Chen S

更新日期：2012-08-01 00:00:00

abstract：CONCLUSION:The risk of operation-requiring postoperative bleeding after abscess tonsillectomy is no different from the risk after elective tonsillectomy. However, the risk is higher for older than for younger patients, both for the whole cohort and for tonsillectomy à chaud. OBJECTIVE:The objective of the present stud...

journal_title：Acta oto-laryngologica

authors： Akin RC,Holst R,Schousboe LP

更新日期：2012-07-01 00:00:00

abstract：CONCLUSION:Otolith organs input influences the axis of horizontal semicircular canal ocular reflex; therefore, the plane of compensatory eye movements induced by the horizontal canal stimulation is not always parallel to the canal. OBJECTIVE:To clarify whether horizontal canal ocular reflex is influenced by otolith or...

journal_title：Acta oto-laryngologica

authors： Ichijo H

更新日期：2012-07-01 00:00:00

abstract：CONCLUSION:The data suggest that histamine up-regulates MUC2 gene regulation and mucin production in airway epithelial cells through histamine 1 receptor (H1R). Histamine appears to play an important role in the early phase of mucin regulation, which might be effectively blocked by an H1R antagonist. OBJECTIVE:Histami...

journal_title：Acta oto-laryngologica

authors： Kim HM,Lee CH,Rhee CS

更新日期：2012-06-01 00:00:00

abstract：CONCLUSION:Systemic application of human mesenchymal stem cells (hMSCs) may be another effective tool for stem cell supply to the inner ear. OBJECTIVES:Most researchers have used local application to provide the inner ear with stem cells. In spite of their efficacy, these methods can potentially cause irreversible dam...

journal_title：Acta oto-laryngologica

authors： Choi BY,Song JJ,Chang SO,Kim SU,Oh SH

更新日期：2012-06-01 00:00:00

abstract：UNLABELLED:Abstract Conclusion: The selected scFv antibody could specifically recognize and target nasopharyngeal carcinoma (NPC), and could be applied to clinical diagnosis and therapy. OBJECTIVE:The aim was to construct and screen fully human anti-NPC single chain Fv fusion phage libraries, and to identify the sp...

journal_title：Acta oto-laryngologica

authors： Li YD,Li YH,Zhao Y,Wang JJ,Xie PL,Guo FJ,Ren CP,Li GC

更新日期：2012-06-01 00:00:00

abstract：:Abstract Usage of the Vibrant Soundbridge (VSB) with round window (RW)-Coupler placement at the RW has been shown to successfully treat mixed hearing loss. Coupling between the VSB's floating mass transducer (FMT) and the RW membrane is difficult in the case of sclerosis in the RW and drilling down the bony lip unti...

journal_title：Acta oto-laryngologica

authors： Iwasaki S,Suzuki H,Moteki H,Miyagawa M,Takumi Y,Usami S

更新日期：2012-06-01 00:00:00

abstract：CONCLUSION:The results suggest that the beneficial effect of astragaloside IV on impulse noise-induced hearing loss may be due to its ability to inhibit reactive oxygen species (ROS) and prevent apoptosis. OBJECTIVE:Astragaloside IV is the major active constituent of Astragalus membranaceus, which has been widely used...

journal_title：Acta oto-laryngologica

authors： Xiong M,He Q,Lai H,Wang J

更新日期：2012-05-01 00:00:00

abstract：CONCLUSIONS:Our preliminary results indicate that mastoidectomy by reconstruction of the posterior wall and obliteration (MAPRO) avoided the disadvantages of a canal-wall-down mastoidectomy. MAPRO effectively prevented cholesteatoma recurrence, provided an excellent basis for hearing restoration, and was generally wate...

journal_title：Acta oto-laryngologica

authors： Kronenberg J,Shapira Y,Migirov L

更新日期：2012-04-01 00:00:00

abstract：CONCLUSIONS:Flat-panel cone-beam computed tomography (CBCT) is able to assess the trajectory of the implanted cochlear implant (CI) array. This is essential to determine specific effects of electrode design and surgical innovations on outcomes in cochlear implantation. CBCT is a non-invasive approach yielding similar d...

journal_title：Acta oto-laryngologica

authors： Cushing SL,Daly MJ,Treaba CG,Chan H,Irish JC,Blaser S,Gordon KA,Papsin BC

更新日期：2012-04-01 00:00:00

abstract：CONCLUSIONS:1. The principle of bilateral symmetry depends on the chordal cartilage that is the keystone in cranial base ossification in rats and humans, due to its anatomical situation and for the production of the chordin protein that regulates the bone morphogenetic protein BMP-7. 2. In humans and in rats, foramen l...

journal_title：Acta oto-laryngologica

authors： Santaolalla-Montoya F,Martinez-Ibargüen A,Sánchez-Fernández JM,Sánchez-del-Rey A

更新日期：2012-04-01 00:00:00

abstract：CONCLUSION:Contrast enhancement of the inner ear by three-dimensional fluid-attenuated inversion recovery magnetic resonance imaging (3D-FLAIR MRI) taken 4 h after intravenous gadolinium (Gd) injection was better than when taken at 10 min. Using heavily T2-weighted 3D-FLAIR MRI, visualization of endolymphatic hydrops (...

journal_title：Acta oto-laryngologica

authors： Sano R,Teranishi M,Yamazaki M,Isoda H,Naganawa S,Sone M,Hiramatsu M,Yoshida T,Suzuki H,Nakashima T

更新日期：2012-03-01 00:00:00

abstract：CONCLUSION:The results suggested mercury (Hg)-induced anomalies in the brainstem-mediated acoustic stapedius muscle reflex in children. OBJECTIVES:Hg exposure has been associated with hearing impairment and brainstem anomalies. Acoustic stapedius reflex (ASR) thresholds, growth functions, decay/adaptation times, and b...

journal_title：Acta oto-laryngologica

authors： Counter SA,Buchanan LH,Ortega F

更新日期：2012-01-01 00:00:00

abstract：:The aim of this study was to evaluate the effects of argon laser irradiation of the semicircular canals using computed tomography (CT) images and to examine the basis for laser treatment for benign paroxysmal positional vertigo (BPPV). CT images of the posterior canal were evaluated postoperatively in a patient with i...

journal_title：Acta oto-laryngologica

authors： Nomura Y,Kobayashi H

更新日期：2012-01-01 00:00:00

abstract：CONCLUSION:A simple measuring box to determine lip-shift angle and eye-width narrowing offered simultaneous and objective data on outcome dysfunction. The method is as easy as visual approaches. The method is objective and as easy as visual access. It is practical for routine clinical use in any clinic. OBJECTIVES:The...

journal_title：Acta oto-laryngologica

authors： Saito H

更新日期：2012-01-01 00:00:00

abstract：CONCLUSIONS:We suggest that age-induced changes of serotonin, N-methyl-d-aspartate receptor (NMDAR), and glutamate decarboxylase (GAD) expression in rats are dependent on the specific location in the central auditory system (CAS). OBJECTIVES:Despite the importance of understanding changes in neurotransmitters during p...

journal_title：Acta oto-laryngologica

authors： Shim HJ,Lee LH,Huh Y,Lee SY,Yeo SG

更新日期：2012-01-01 00:00:00

abstract：CONCLUSION:Cochleostomy is the most efficient approach in delivering PEG-b-PCL polymersomes (PMs) to the inner ear. PMs can be delivered to the vestibule by transtympanic injection or cochleostomy. OBJECTIVE:To evaluate the efficiency of delivering PEG-b-PCL PMs into the inner ear using different approaches. METHODS:...

journal_title：Acta oto-laryngologica

authors： Zhang Y,Zhang W,Johnston AH,Newman TA,Pyykk I,Zou J

更新日期：2011-12-01 00:00:00

abstract：CONCLUSION:The chewing gum indirectly affects postural control by influencing vestibular function to stabilize posture during upright standing. OBJECTIVES:This study aimed to evaluate the effect of chewing gum on static posturography in patients. METHODS:The subjects were 26 patients with chronic balance disorders. T...

journal_title：Acta oto-laryngologica

authors： Goto F,Kushiro K,Tsutsumi T

更新日期：2011-11-01 00:00:00

abstract：CONCLUSION:The occult metastasis rate for T2 oral cancer can be reduced by ultrasonography (US). Also, the late metastasis rate is considered to be reduced by combining US with frozen section biopsy (FSB) during supraomohyoid neck dissection (SOHND). OBJECTIVES:Early oral cancer has been reported to show occult metast...

journal_title：Acta oto-laryngologica

authors： Lee K,Nishikawa S,Yoshimura K,Kawata R

更新日期：2011-11-01 00:00:00

abstract：CONCLUSION:The average recovery of hearing and cessation of tinnitus was significantly better after treatment with Radix Astragali (RA) than after non-treatment with RA. RA can be valuable adjuvant therapy for patients with acute acoustic trauma (AAT). OBJECTIVES:AAT is one of the early indications for the use of RA. ...

journal_title：Acta oto-laryngologica

authors： Xiong M,He Q,Lai H,Huang W,Wang L,Yang C,Wang J

更新日期：2011-10-01 00:00:00

abstract：CONCLUSIONS:Congenital cytomegalovirus (CMV) infection is a major cause of bilateral and unilateral sensorineural hearing loss (SNHL) in children, accounting for 9.0% of SNHL cases. The diagnostic rate using combined genetic deafness test and CMV DNA detection test was determined to be 46.4% in bilateral profound SNHL....

journal_title：Acta oto-laryngologica

authors： Furutate S,Iwasaki S,Nishio SY,Moteki H,Usami S

更新日期：2011-09-01 00:00:00

abstract：CONCLUSIONS:Analysis of the complete mtDNA genome and X-linkage of this five-generation Chinese family revealed that the 1555A > G mutation may lead to deafness. OBJECTIVES:Mutations in mitochondrial DNA (mtDNA) have been found to be associated with sensorineural hearing loss. However, the variable clinical phenotype ...

journal_title：Acta oto-laryngologica

authors： Men M,Jiang L,Wang H,Liu Y,Hu Z,He C,Feng Y

更新日期：2011-09-01 00:00:00

abstract：UNLABELLED:Abstract Conclusions: In survival analysis, the combined Charlson comorbidity index (CCI) can be considered as a prognostic factor independent of the tumor node metastasis (TNM) classification, tumor stage, and tumor location. Severe comorbidity was the factor that had the greatest impact on prognosis in cas...

journal_title：Acta oto-laryngologica

authors： Gimeno-Hernández J,Iglesias-Moreno MC,Gómez-Serrano M,Carricondo F,Gil-Loyzaga P,Poch-Broto J

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to compare the radiologic findings with histological results of anatomically matched whole organ sections and to analyze the accuracy of pretherapeutic radiologic staging of glottic cancers. METHODS:The histologic findings of surgical specimens of 30 patients who had undergone tota...

journal_title：Acta oto-laryngologica

authors： Lim JY,Park IS,Park SW,Kim JW,Kim YM

更新日期：2011-08-01 00:00:00

abstract：:Sigmoid sinus diverticulum-induced pulsatile tinnitus is a rare medical problem. Here we report a case where pulsatile tinnitus occurred in the perimenopause with evidence of sigmoid sinus diverticulum. The tinnitus disappeared with the restoration of hearing after surgery. While diagnosis is critical for the treatmen...

journal_title：Acta oto-laryngologica

authors： Hou ZQ,Han DY

更新日期：2011-08-01 00:00:00

abstract：CONCLUSION:The visual outcomes of endoscopic treatment of optic neuropathy are favorable. However, no specific prognostic factor was associated with good outcome. OBJECTIVE:To investigate visual outcomes of patients with optic neuropathy caused by paranasal mucocele or sinusitis. METHODS:The clinical course in 38 pat...

journal_title：Acta oto-laryngologica

authors： Nakaya K,Oshima T,Kudo T,Ikeda R,Hidaka H,Kobayashi T

更新日期：2011-08-01 00:00:00

abstract：CONCLUSION:Mean incudostapedial joint (ISJ) angulation of atretic ears was statistically wider than ISJ angulation of non-atretic ears. Postoperative hearing results in the narrow tympanoplasty type II (T2) subgroup were better than those in the wide T2 subgroup. In cases of abnormally wide ISJ angulation, we recommend...

journal_title：Acta oto-laryngologica

authors： Kim DW,Lee JH,Song JJ,Chang H,Choi YS,Jang JH,Kim JH,Oh SH,Chang SO

更新日期：2011-07-01 00:00:00